Valorisation of phenols to coumarins through one-pot palladium-catalysed double C–H functionalizations
Giulia Brufani, Federica Valentini, Flavio Sabatelli, Benedetta Di Erasmo, Anastasiia M. Afanasenko, Chao‐Jun Li, Luigi Vaccaro
Abstract
Herein a one-pot double C–H functionalization for constructing C8-alkyl substituted coumarins from phenols is reported. For the first time Pd/C as heterogenous catalyst was used to enable the synthesis of structurally divers coumarins.
Topics & Concepts
PhenolsPalladiumChemistryCatalysisSurface modificationAlkylOrganic chemistryHalogenationCombinatorial chemistryPhysical chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques