Intracerebral haemorrhage: from clinical settings to animal models
Qian Bai, Zhao‐Fu Sheng, Yang Liu, Ruiyi Zhang, V. Wee Yong, Mengzhou Xue
Abstract
Spontaneous intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity and for which no effective treatments are available to date. Much experimental and clinical research have been performed to explore its mechanisms regard the subsequent inflammatory cascade and to seek the potential therapeutic strategies. The aim of this review is to discuss insights from clinical settings that have led to the development of numerous animal models of ICH. Some of the current and future challenges for clinicians to understand ICH are also surveyed.
Topics & Concepts
Intensive care medicineMedicineStroke (engine)Animal modelInternal medicineEngineeringMechanical engineeringIntracerebral and Subarachnoid Hemorrhage ResearchAcute Ischemic Stroke ManagementCancer-related gene regulation