Electrochemical Annulation of <i>p</i>-Alkoxy or <i>p</i>-Hydroxy Anilines with Enaminones for Selective Indole and Benzofuran Synthesis

Abstract

The green and sustainable electrochemical oxidative cyclization of enaminones with p -methoxy/ p -hydroxy anilines has been developed, enabling the regioselective synthesis of indoles and benzofurans. The methods are of significant advantage not only due to the mild and metal-free sustainable electrochemical conditions, but also because of the employment of easily available and stable aniline substrates to replace the unstable quinoneimide for a similar annulation in previous work.

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