Exosomes can make the use of circulating miRNA as a biomarker more feasible. The aim of gene therapy should be to learn everything there is to know about miRNA activity.
Moataz Dowaidar
Abstract
Circulating miRNAs have also been propos Exosomes can make the use ofcirculating miRNA as a biomarker more feasible. The aim of gene therapy shouldbe to learn everything there is to know about miRNA activity. ed as potentialdisease biomarkers. It is critical for precision medicine to provide a system thatallows for the rapid verification and confirmation of promising biomarkers basedon circulating miRNAs. Concentrating on specific modes of transport(exosomes), fine-tuning sampling and extraction processes, and absolutequantification without using housekeeping gene (s) could allow the use ofcirculating miRNAs as biomarkers more realistic in the future. You should knowwhich human biological fluid is better for determining the amount of circulatingmiRNA expression, as well as which pathology this biological fluid is best for.To validate the existence of new circulating miRNAs, separate experiments maybe performed. Using a panel of two or more intentionally chosen circulatingmiRNAs with one or more pathologies, such as tumors, will be more accurate andprecise.