Visible-light-induced Ritter-type amidation of α-hydroxy ketones in the selective synthesis of α,α-diamido and monoamido ketones
E. Tang, Quan‐Quan Zhou, Jie‐Ping Wan
Abstract
Visible light-induced, transition metal-free oxidative dehydroxylation and C-H amidation of α-hydroxy ketones involving Ritter-type amidation has been developed, leading to the selective synthesis of α,α-diamido- and α-monoamido ketones with tunable selectivity as well as broad substrate tolerance.
Topics & Concepts
ChemistryRitter reactionSelectivitySubstrate (aquarium)KetoneVisible spectrumTransition metalMedicinal chemistryOrganic chemistryPhotochemistryCatalysisGeologyOceanographyPhysicsOptoelectronicsOxidative Organic Chemistry ReactionsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods