Copper-catalyzed amine-mediated yne-propargylic substitution
Chunyun Jiang, Defu Luo, Xiangjian Meng, Qinqin Cui, Lili Zhao, Jinggong Liu, Shuang Yang, Xinqiang Fang
Abstract
A copper-catalyzed yne-propargylic substitution using amines as nucleophiles has been achieved for the first time, affording a variety of amines having diyne moieties, which are important pharmacophores in many bioactive molecules.
Topics & Concepts
ChemistryAmine gas treatingPharmacophoreSubstitution (logic)CatalysisCopperCombinatorial chemistryNucleophilic substitutionSubstitution reactionMoleculeNucleophileOrganic chemistryMedicinal chemistryStereochemistryComputer scienceProgramming languageCatalytic Alkyne ReactionsCyclization and Aryne ChemistryCatalytic C–H Functionalization Methods