Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candida krusei Recovered from an International Collection
Hazim O. Khalifa, Vít Hubka, Akira Watanabe, Minoru Nagi, Yoshitsugu Miyazaki, Takashi Yaguchi, Katsuhiko Kamei
Abstract
HS1 mutations were the major mechanisms responsible for azole and echinocandin resistance, respectively. Genotyping of our 79 isolates coupled with 217 other isolates from different sources and geography confirmed that the isolates belong to two main subpopulations, with isolates from human clinical material and Asia being more predominant in cluster 1, and environmental and animals isolates and those from Europe in cluster 2. Our results are of critical concern, since realizing that the C. krusei resistance mechanisms and their genotyping are crucial for guiding specific therapy and for exploring the potential infection source.
Topics & Concepts
EchinocandinMicafunginFluconazoleCaspofunginCandida kruseiGenotypingBiologyAzoleMicrobiologyAnidulafunginDrug resistanceCandida glabrataVoriconazoleFlucytosineAntifungalGenotypeGeneGeneticsAntifungal resistance and susceptibilityInfectious Diseases and MycologyPlant Pathogens and Fungal Diseases