A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway
Jia-yi You, Xinwei Liu, Ying-xia Bao, Zheng-nan Shen, Quan Wang, Gong-yun He, Jing Lü, Jiguo Zhang, Jianwen Chen, Peiqing Liu
Topics & Concepts
CREBCyclic guanosine monophosphatePhosphodiesteraseNeuroprotectionPharmacologyMedicineApoptosiscGMP-specific phosphodiesterase type 5IschemiaCyclic adenosine monophosphateInternal medicineChemistryReceptorSildenafilBiochemistryNitric oxideEnzymeTranscription factorGenePhosphodiesterase function and regulationHistone Deacetylase Inhibitors ResearchNitric Oxide and Endothelin Effects