Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
Zhong Y. Yeow, Bramwell G. Lambrus, Rebecca Marlow, Kevin Zhan, Mary-Anne Durin, Lauren T. Evans, Phillip M. Scott, Thao P. Phan, Elizabeth M. Park, Lorena A. Ruiz, Daniela Moralli, Eleanor Knight, Luned Badder, Daniela Novo, Syed Haider, Catherine Green, Andrew Tutt, Christopher J. Lord, J. Ross Chapman, Andrew J. Holland
Topics & Concepts
CentrosomeGenome instabilityMitosisAmpliconBiologyCancer researchBreast cancerPLK1Cell biologyCancerGeneticsComputational biologyGeneDNA damageCell cycleDNAPolymerase chain reactionPARP inhibition in cancer therapyCRISPR and Genetic EngineeringDNA Repair Mechanisms