Seed-competent tau monomer initiates pathology in a tauopathy mouse model
Hilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Łukasz A. Joachimiak, Marc I. Diamond
Abstract
thus constitutes the first detectable step in the initiation of tauopathy in this mouse model, with obvious implications for the origins of tauopathy in humans.
Topics & Concepts
TauopathyFibrilTau proteinMonomerChemistryPhosphorylationMutantCell biologyBiochemistryBiophysicsBiologyNeurodegenerationAlzheimer's diseaseDiseasePathologyMedicinePolymerGeneOrganic chemistryAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research