Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance
John O. Miners, Thomas M. Polasek, Julie-Ann Hulin, Andrew Rowland, Robyn Meech
Topics & Concepts
GlucuronidationDrugPharmacologyGlucuronosyltransferaseMechanism (biology)Drug interactionChemistryEnzymeDrug metabolismMedicineBiochemistryMicrosomeEpistemologyPhilosophyPharmacogenetics and Drug MetabolismNeonatal Health and BiochemistryBlood disorders and treatments