Mitochondria-localized <i>in situ</i> generation of rhodamine photocage with fluorescence turn-on enabling cancer cell-specific drug delivery triggered by green light
Amrita Paul, Rakesh Mengji, Manoranjan Bera, Mamata Ojha, Avijit Jana, N. D. Pradeep Singh
Abstract
In this work, we have developed a rhodamine dye based water-soluble, mitochondria-indicating photocage, which gets activated in the mitochondria producing a fluorescent signal and on-demand releases the caged anticancer drug, chlorambucil, in the cancer cells selectively upon irradiation of green light.
Topics & Concepts
In situFluorescenceMitochondrionDrug deliveryCancer cellRhodamineChemistryTurn (biochemistry)BiophysicsCellNanotechnologyPhotochemistryCombinatorial chemistryBiochemistryCancerMaterials scienceBiologyOpticsPhysicsOrganic chemistryGeneticsPhotochromic and Fluorescence ChemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research Studies