Design, Synthesis, and Bioevaluation of Indole Core Containing 2-Arylidine Derivatives of Thiazolopyrimidine as Multitarget Inhibitors of Cholinesterases and Monoamine Oxidase A/B for the Treatment of Alzheimer Disease
Muhammad Shahid Nadeem, Jalaluddin Azam Khan, Imran Kazmi, Umer Rashid
Abstract
results via binding orientations and interaction patterns of the synthesized compounds into the binding sites of target enzymes. We have successfully identified safe, non-neurotoxic, and blood brain barrier permeable multitarget lead compounds for the treatment of AD.
Topics & Concepts
ChemistryMonoamine oxidaseMonoamine oxidase BDocking (animal)EnzymeMonoamine neurotransmitterPharmacologyIn vivoIC50In vitroLinkerAcute toxicityMonoamine oxidase APotencyStereochemistryBiochemistryToxicityOrganic chemistryReceptorOperating systemSerotoninBiotechnologyMedicineNursingBiologyComputer scienceCholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionComputational Drug Discovery Methods