Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis
Sander N. Goossens, Samantha L. Sampson, Annelies Van Rie
Abstract
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug tolerance. We summarize findings on M. tuberculosis tolerance published in the past 20 years. Key M. tuberculosis responses to drug pressure are reduced growth rates, metabolic shifting, and the promotion of efflux pump activity.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisDrug toleranceDrugMedicineMicrobiologyVirologyImmunologyBiologyPharmacologyPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis