Purple tea water extract blocks RANKL-induced osteoclastogenesis through modulation of Akt/GSK3β and Blimp1-Irf8 pathways
Yuxin Zhang, Jing Wang, Chenxu Jing, Ming-Xue Zhou, Wenqi Jin, Xiuci Yan, Huanhuan Hou, Kai Shi, Wanchun Sun, Liwei Sun
Abstract
PTE administration ameliorated bone loss in LPS-treated mice. Taken together, the results presented in this work suggest that PTE treatment possesses anti-osteolytic activity.
Topics & Concepts
RANKLProtein kinase BChemistryCell biologyModulation (music)PI3K/AKT/mTOR pathwayCancer researchSignal transductionBiochemistryBiologyPhysicsReceptorAcousticsActivator (genetics)Bone Metabolism and DiseasesBone health and treatmentsOsteomyelitis and Bone Disorders Research