Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications
Laura Goracci, Jenny Desantis, Aurora Valeri, Beatrice Castellani, Michela Eleuteri, Gabriele Cruciani
Abstract
AOX) for more in-depth data interpretation, and both enzymes resulted in active PROTAC metabolism.
Topics & Concepts
ChemistryProteolysisBiochemistryMetabolismCYP3A4Cytochrome P450EnzymeProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research