Catalytic asymmetric construction of helicenes <i>via</i> transformation of biaryls
Peiling Fan, Lun Li, Deyun Qian
Abstract
This review showcases a systematic overview of the available tools for the catalytic asymmetric transformation of biaryl substrates toward the construction of challenging enantioenriched helicenes and the conceptual aspects associated with each type of transformation. Depending on the properties of the biaryl and the nature of the process, several methodologies have been developed, including olefin metathesis, hydroarylation of alkynes, C-X (X = C, O, N) coupling, and C-H functionalization. Pioneering studies and an array of representative reactions are discussed to underscore the potential of these synthetic protocols.
Topics & Concepts
CatalysisTransformation (genetics)Combinatorial chemistryOlefin fiberEnantioselective synthesisOlefin metathesisMetathesisSurface modificationChemistryComputer scienceOrganic chemistryPolymerPolymerizationPhysical chemistryBiochemistryGeneSynthesis and Properties of Aromatic CompoundsAxial and Atropisomeric Chirality SynthesisPhotochromic and Fluorescence Chemistry