Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2
Ikumi Kuriwaki, Minoru Kameda, Hiroyuki Hisamichi, Shigetoshi Kikuchi, Kazuhiko Iikubo, Yuichiro Kawamoto, Hiroyuki Moritomo, Yutaka Kondoh, Y. Amano, Y. Tateishi, Yuka Echizen, Yoshinori Iwai, Atsushi Noda, Hiroshi Tomiyama, Tomoyuki Suzuki, Masaaki Hirano
Topics & Concepts
ChemistryPyrimidineFibroblast growth factor receptorFibroblast growth factor receptor 1SelectivityKinase insert domain receptorTriazineFibroblast growth factorStructure–activity relationshipStereochemistryVEGF receptorsVascular endothelial growth factorReceptorBiochemistryPharmacologyCancer researchIn vitroVascular endothelial growth factor ABiologyCatalysisPolymer chemistryFibroblast Growth Factor ResearchEosinophilic Disorders and SyndromesKruppel-like factors research