Increased Expression and Amplification of <i>bla</i> <sub>KPC-2</sub> Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain
Xinhui Li, Jisheng Zhang, Chengru Yang, Jie Li, Jianmin Wang, Wan Huang, Lingyi Zeng, Xushan Liang, Wenzhang Long, Xiaoli Zhang
Abstract
Klebsiella pneumoniae carbapenemase (KPC) production is the most common mechanism of K. pneumoniae resistance to carbapenems in China. Currently, CAZ/AVI is considered a potential alternative therapeutic option for infections caused by these isolates.
Topics & Concepts
Klebsiella pneumoniaeBiologyCeftazidimeMicrobiologyPlasmidAntibiotic resistanceCeftazidime/avibactamAvibactamAntibioticsGeneticsGeneEscherichia coliBacteriaPseudomonas aeruginosaAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingAntibiotics Pharmacokinetics and Efficacy