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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

Xiaofeng Qi, Lucas M. Friedberg, Ryan De Bose-Boyd, Tao Long, Xiaochun Li

2020Nature Chemical Biology86 citationsDOIOpen Access PDF

Topics & Concepts

SmoothenedHedgehog signaling pathwayHedgehogG protein-coupled receptorTransmembrane domainChemistryBiologyBiochemistryCell biologySignal transductionReceptorHedgehog Signaling Pathway StudiesGenomics and Chromatin DynamicsCancer-related gene regulation
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling | Litcius