Direct mechanocatalysis by resonant acoustic mixing (RAM)
Cameron B. Lennox, Tristan H. Borchers, Lori Gonnet, Christopher J. Barrett, Stefan G. Koenig, Karthik Nagapudi, Tomislav Friščić
Abstract
a combination of benzyl azide formation and CuAAC reactions on a wide scope of reagents, provides control over reaction stoichiometry that is herein shown to be superior to that seen in solution or by using more conventional CuCl catalyst, and is applied for simple gram-scale synthesis of the anticonvulsant drug Rufinamide.
Topics & Concepts
Mixing (physics)AcousticsComputer scienceMaterials sciencePhysicsQuantum mechanicsCrystallography and molecular interactionsChemical Synthesis and AnalysisMicrofluidic and Capillary Electrophoresis Applications