Novel Peptide from Commensal Staphylococcus simulans Blocks Methicillin-Resistant Staphylococcus aureus Quorum Sensing and Protects Host Skin from Damage
Morgan M. Brown, Jakub Kwieciński, Luis Mejia Cruz, Ali Shahbandi, Daniel A. Todd, Nadja B. Cech, Alexander R. Horswill
Abstract
in competition with MRSA reduced dermonecrotic and epicutaneous skin injury in murine models. The addition of synthetic AIP-I also effectively reduced MRSA dermonecrosis and epicutaneous skin injury in murine models. These results demonstrate potent anti-MRSA quorum sensing inhibition by a rare human skin commensal and suggest that cross talk between CoNS and MRSA may be important in maintaining healthy skin homeostasis and preventing MRSA skin damage during colonization or acute infection.
Topics & Concepts
Staphylococcus aureusQuorum sensingMicrobiologyBiologyMethicillin-resistant Staphylococcus aureusColonizationSkin infectionStaphylococcal infectionsStaphylococcal Skin InfectionsStaphylococcusVirulenceGeneBacteriaGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities