Treatment of Gut Fermentation Syndrome With Fecal Microbiota Transplantation
Elisabeth Vandekerckhove, Filip Janssens, David J. Tate, Danny De Looze
Abstract
Letters17 November 2020Treatment of Gut Fermentation Syndrome With Fecal Microbiota TransplantationElisabeth Vandekerckhove, MD, Filip Janssens, MD, David Tate, MD, PhD, and Danny De Looze, MD, PhDElisabeth Vandekerckhove, MDUniversity Hospital Ghent, Ghent, Belgium (E.V., D.T., D.D.), Filip Janssens, MDJesse Hospital, Hasselt, Belgium (F.J.), David Tate, MD, PhDUniversity Hospital Ghent, Ghent, Belgium (E.V., D.T., D.D.), and Danny De Looze, MD, PhDUniversity Hospital Ghent, Ghent, Belgium (E.V., D.T., D.D.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-0341 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Gut fermentation syndrome, also known as auto-brewery syndrome, is a rare condition in which endogenous ethanol production in the gut after carbohydrate-rich meals leads to elevated blood alcohol levels, a feeling of drunkenness, variably disturbed liver function, and other indications of ethanol intoxication. Most reports have assumed that the mechanism of ethanol production involves carbohydrate fermentation by excessive fungal growth in the gut (1, 2).Objective: To report what we believe is the first successful treatment of a patient with chronic gut fermentation syndrome by using fecal microbiota transplantation.Case Report: In 2016, we cared for a 47-year-old man ...References1. Kaji H, Asanuma Y, Yahara O, et al. Intragastrointestinal alcohol fermentation syndrome: report of two cases and review of the literature. J Forensic Sci Soc. 1984;24:461-71. [PMID: 6520589] CrossrefMedlineGoogle Scholar2. Cordell B, McCarthy J. A case study of gut fermentation syndrome (auto-brewery) with Saccharomyces cerevisiae as the causative organism. Int J Clin Med. 2013;4:309-12. doi:10.4236/ijcm.2013.47054 CrossrefGoogle Scholar3. Hafez EM, Hamad MA, Fouad M, et al. Auto-brewery syndrome: ethanol pseudo-toxicity in diabetic and hepatic patients. Hum Exp Toxicol. 2017;36:445-450. [PMID: 27492480] doi:10.1177/0960327116661400 CrossrefMedlineGoogle Scholar4. Malik F, Wickremesinghe P, Saverimuttu J. Case report and literature review of auto-brewery syndrome: probably an underdiagnosed medical condition. BMJ Open Gastroenterol. 2019;6:e000325. [PMID: 31423320] doi:10.1136/bmjgast-2019-000325 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Ghent, Ghent, Belgium (E.V., D.T., D.D.)Jesse Hospital, Hasselt, Belgium (F.J.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-0341.Corresponding Author: Danny De Looze, MD, PhD, University Hospital Ghent, Corneel Heymanslaan 10, Ghent 9000, Belgium; e-mail, danny.[email protected]be.This article was published at Annals.org on 18 August 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndogenous Ethanol and Triglyceride Production by Gut Pichia kudriavzevii, Candida albicans and Candida glabrata Yeasts in Non-Alcoholic SteatohepatitisMicrobiome Therapeutics: A Path Toward Sustainable HealthcareEncyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseasesThe Auto-Brewery Syndrome: A Perfect Metabolic "Storm" with Clinical and Forensic ImplicationsGut fermentation syndrome: A systematic review of case reportsGut Flora-Mediated Metabolic Health, the Risk Produced by Dietary Exposure to Acetamiprid and TebuconazoleFactors in an Auto-Brewery Syndrome group compared to an American Gut Project group: a case-control study 17 November 2020Volume 173, Issue 10Page: 855KeywordsAlcoholsBloodEmotionsEthanolLiver function testsPatientsSurgeryTransplantationUltrasound imagingUpper respiratory tract infections ePublished: 18 August 2020 Issue Published: 17 November 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...