Design of balanced dual-target inhibitors of EGFR and microtubule
Yifan Liu, Qiu-Ya Ma, Xiangyu Kong, Xinyao Huo, Zongyue Dong, Yan Ma, Kehao Yang, Weiwei Niu, Kai Zhang
Topics & Concepts
GefitinibChemistryMicrotubuleProtein kinase BKinaseTyrosine kinaseQuinazolineMicrotubule polymerizationMAPK/ERK pathwayTubulinCancer researchEpidermal growth factor receptorA549 cellCell cycle checkpointEGFR inhibitorsIn vitroPharmacologyApoptosisCell cycleCell biologyBiochemistrySignal transductionBiologyReceptorCombinatorial chemistryHER2/EGFR in Cancer ResearchCancer therapeutics and mechanismsQuinazolinone synthesis and applications