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Metal–Organic Layers Hierarchically Integrate Three Synergistic Active Sites for Tandem Catalysis

Yangjian Quan, Guangxu Lan, Wenjie Shi, Ziwan Xu, Yingjie Fan, Eric You, Xiaomin Jiang, Cheng Wang, Wenbin Lin

2020Angewandte Chemie International Edition44 citationsDOIOpen Access PDF

Abstract

Abstract We report the design of a bifunctional metal–organic layer (MOL), Hf 12 ‐Ru‐Co, composed of [Ru(DBB)(bpy) 2 ] 2+ [DBB‐Ru, DBB=4,4′‐di(4‐benzoato)‐2,2′‐bipyridine; bpy=2,2′‐bipyridine] connecting ligand as a photosensitizer and Co(dmgH) 2 (PPA)Cl (PPA‐Co, dmgH=dimethylglyoxime; PPA=4‐pyridinepropionic acid) on the Hf 12 secondary building unit (SBU) as a hydrogen‐transfer catalyst. Hf 12 ‐Ru‐Co efficiently catalyzed acceptorless dehydrogenation of indolines and tetrahydroquinolines to afford indoles and quinolones. We extended this strategy to prepare Hf 12 ‐Ru‐Co‐OTf MOL with a [Ru(DBB)(bpy) 2 ] 2+ photosensitizer and Hf 12 SBU capped with triflate as strong Lewis acids and PPA‐Co as a hydrogen transfer catalyst. With three synergistic active sites, Hf 12 ‐Ru‐Co‐OTf competently catalyzed dehydrogenative tandem transformations of indolines with alkenes or aldehydes to afford 3‐alkylindoles and bisindolylmethanes with turnover numbers of up to 500 and 460, respectively, illustrating the potential use of MOLs in constructing novel multifunctional heterogeneous catalysts.

Topics & Concepts

BifunctionalChemistryCatalysisDimethylglyoximeTrifluoromethanesulfonateDehydrogenationCombinatorial chemistryRutheniumBipyridineCationic polymerizationMetal-organic frameworkTandemLigand (biochemistry)Medicinal chemistryCobaltOrganic chemistryCrystal structureMaterials scienceComposite materialBiochemistryReceptorAdsorptionMetal-Organic Frameworks: Synthesis and ApplicationsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis
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