Pulmonary circulation-mediated heart targeting for the prevention of heart failure by inhalation of intrinsically bioactive nanoparticles
Chao Liu, Liyuan Chen, Yongchang Ma, Kaiyao Hu, Peng Wu, Lina Pan, Haiyan Chen, Lanlan Li, Houyuan Hu, Jianxiang Zhang
Abstract
Inhalation delivery of nanoparticles is an effective, safe, and noninvasive strategy for targeted treatment of heart diseases. TPCD NP-based nanotherapies are promising drugs for heart failure and other acute/chronic heart diseases associated with oxidative stress.
Topics & Concepts
In vivoInhalationPharmacologyHeart failureOxidative stressReactive oxygen speciesChemistryMitochondrial ROSDoxorubicinInternalizationMitochondrionIn vitroMedicineCancer researchCellBiochemistryBiologyCardiologyChemotherapyInternal medicineAnesthesiaBiotechnologyInhalation and Respiratory Drug DeliveryMXene and MAX Phase MaterialsGraphene and Nanomaterials Applications