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New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer's disease: Design, synthesis, and biological evaluation

Burcu Kılıç, Merve Bardakkaya, Rahşan Ilıkçı Sağkan, Fatma Aksakal, Shakila Shakila, Deniz S. Doğruer

2022Bioorganic Chemistry34 citationsDOI

Topics & Concepts

ChemistryBenzamideThioureaButyrylcholinesteraseCholinesteraseIC50CytotoxicityStereochemistryPharmacologyBiochemistryEnzymeAchéAcetylcholinesteraseOrganic chemistryIn vitroMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsFree Radicals and Antioxidants
New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer's disease: Design, synthesis, and biological evaluation | Litcius