Direct detection of human adenovirus or SARS-CoV-2 with ability to inform infectivity using DNA aptamer-nanopore sensors
Ana Sol Peinetti, Ryan J. Lake, Wen Cong, Laura Cooper, Yuting Wu, Yuan Ma, Gregory T. Pawel, María Eugenia Toimil‐Molares, C. Trautmann, Lijun Rong, Benito J. Mariñas, Omar Azzaroni, Yi Lu
Abstract
copies/ml for SARS-CoV-2. Applications of the aptamer-nanopore sensors in different types of water samples, saliva, and serum are demonstrated for both enveloped and nonenveloped viruses, making the sensor generally applicable for detecting these and other emerging viruses of environmental and public health concern.
Topics & Concepts
InfectivitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AptamerNanoporeVirologyCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakCoronavirusDNASars virusCoronavirus InfectionsBetacoronavirusComputational biologyNanopore sequencingBiologyVirusNanotechnologyDNA sequencingMedicineGeneticsInfectious disease (medical specialty)Materials scienceDiseaseOutbreakPathologyNanopore and Nanochannel Transport StudiesAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testing