Safety and Effect of a Low- and High-Dose Multi-Strain Probiotic Supplement on Microbiota in a General Adult Population: A Randomized, Double-Blind, Placebo-Controlled Study
Annie Tremblay, Asmaa Fatani, Amanda Ford, Amanda Piano, Varuni Nagulesapillai, Jérémie Auger, Chad W. MacPherson, Mary C. Christman, Thomas A. Tompkins, Wendy J. Dahl
Abstract
. The formulation was well tolerated in this sample of the general adult population, even at the higher dose. The strains appear to have influenced microbiota composition minimally, as expected in the absence of dysbiosis, and consistently with the dose administered. Overall, the results provide a rationale to study the effects this formulation on microbiota composition in individuals exhibiting dysbiosis associated with metabolic disorders or obesity.
Topics & Concepts
Bifidobacterium breveBifidobacterium longumPediococcus acidilacticiLactobacillus rhamnosusProbioticPopulationLactobacillusBifidobacteriumBiologyLactobacillus caseiLactobacillus paracaseiMicrobiologyPersistence (discontinuity)Lactobacillus plantarumFood scienceMedicineFermentationBacteriaLactic acidGeneticsGeotechnical engineeringEnvironmental healthEngineeringGut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens research