CF<sub>2</sub>DSO<sub>2</sub>Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation
Junqing Liang, Gangao Wang, Lefeng Dong, Xiwen Pang, Jiawei Qin, Xiaoyong Xu, Xusheng Shao, Zhong Li
Abstract
D) are important functional groups in pharmaceutical and agrochemical compounds, and the introduction of these functional groups remains a challenging. We herein report a robust reagent for deuteriodifluoromethylthiolation and deuteriodifluoromethylation. Its potentials were successfully showcased by deuteriodifluoromethylation and deuteriodifluoromethylthiolation of indoles with high-level deuterium incorporation. The reagent also has potential for deuteriodifluoromethylation and deuteriodifluoromethylthiolation of wide range of other natural or synthetic bioactive molecules.
Topics & Concepts
ReagentChemistryCombinatorial chemistryMoleculeFunctional groupOrganic chemistryPolymerFluorine in Organic ChemistryChemical Reactions and IsotopesInorganic Fluorides and Related Compounds