Recovery of a triazole-resistant Aspergillus fumigatus in respiratory specimen of COVID-19 patient in ICU – A case report
Théo Ghelfenstein-Ferreira, Anastasia Saade, Alexandre Alanio, Stéphane Bretagne, Raffael Júnio Araújo de Castro, Samia Hamane, Élie Azoulay, Swann Bredin, Sarah Dellière
Abstract
Although invasive pulmonary aspergillosis (IPA) is typically described in immunocompromised host, patient with severe influenzae can develop IPA. Similarly, patients with severe COVID-19 complicated with IPA are increasingly reported. Here, we describe a case of invasive aspergillosis with triazole-resistant A. fumigatus (TR34/L98H mutation) in a 56-year-old patient with COVID-19 in intensive care unit. This report highlights the need to define the available tools for diagnosis of invasive aspergillosis in severe COVID-19 patients.
Topics & Concepts
Aspergillus fumigatusAspergillosisMedicineVoriconazoleIntensive care unitCoronavirus disease 2019 (COVID-19)Respiratory systemAspergillusMicrobiologyIntensive care medicineImmunologyInternal medicineAntifungalDermatologyBiologyInfectious disease (medical specialty)DiseaseAntifungal resistance and susceptibilityFungal Infections and StudiesAntimicrobial Resistance in Staphylococcus