The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans
Júlia Catarina Vieira Reuwsaat, Daniel Paiva Agustinho, Heryk Motta, Andrew L. Chang, Holly Brown, Michael R. Brent, Lívia Kmetzsch, Tamara L. Doering
Abstract
The pathogenic yeast Cryptococcus neoformans presents a worldwide threat to human health, especially in the context of immunocompromise, and current antifungal therapy is hindered by cost, limited availability, and inadequate efficacy. After the infectious particle is inhaled, C. neoformans initiates a complex transcriptional program that integrates cellular responses and enables adaptation to the host lung environment.
Topics & Concepts
Cryptococcus neoformansTranscription factorMicrobiologyBiologyPathogenicityCellCell biologyGeneticsGeneFungal Infections and StudiesAntifungal resistance and susceptibilityParasitic Infections and Diagnostics