Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling
Sakari Mäntyselkä, Kalle Kolari, Philipp Baumert, Laura Ylä‐Outinen, Lauri Kuikka, Suvi Lahtonen, Perttu Permi, Henning Wackerhage, Elina Kalenius, Riikka Kivelä, Juha J. Hulmi
Abstract
The use of glycolytic intermediates for anabolism was demonstrated in both myoblasts and myotubes, which incorporate glucose-derived carbon into proteins, RNA, and lipids. We identify phosphoglycerate dehydrogenase (PHGDH) as a critical enzyme in those processes and also for muscle cell hypertrophy, proliferation, protein synthesis, and mTORC1 signaling. Our results thus suggest that PHGDH in skeletal muscle is more than just a serine-synthesizing enzyme.
Topics & Concepts
mTORC1Pentose phosphate pathwayMyogenesisBiologyBiochemistryGlycolysisC2C12Cell growthSerineCell biologyPI3K/AKT/mTOR pathwaySignal transductionMetabolismMyocyteEnzymeMuscle metabolism and nutritionMuscle Physiology and DisordersMetabolism, Diabetes, and Cancer