Boosting the therapy of glutamine-addiction glioblastoma by combining glutamine metabolism therapy with photo-enhanced chemodynamic therapy
Ling Wang, Yaobao Han, Zhengpeng Gu, Mengxiao Han, Chunhong Hu, Zhen Li
Abstract
, which can be monitored by photoacoustic imaging. The NIR-II light irradiation can generate a large amount of reactive oxygen species (ROS) within a short time to kill tumor cells and enhance the CDT efficacy. This is the first work on the treatment of orthotopic malignant GBM through combined glutamine metabolism therapy and photo-enhanced CDT, and provides insights into the treatment of other solid tumors by modulating the metabolism of tumor cells.
Topics & Concepts
GlutamineGlioblastomaMetabolismChemistryCancer researchPhotodynamic therapyMedicineBiochemistryAmino acidOrganic chemistryCancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentNanoplatforms for cancer theranostics