Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery
Trevor Gonzalez, Aaron Mitchell-Dick, Leo O. Blondel, Marco M. Fanous, Joshua A. Hull, Daniel K. Oh, Sven Møller-Tank, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, Aravind Asokan
Topics & Concepts
CapsidComputational biologyTransduction (biophysics)BiologyGene deliveryAdeno-associated virusTropismGenetic enhancementGeneVector (molecular biology)VirologyGeneticsVirusRecombinant DNABiochemistryVirus-based gene therapy researchCRISPR and Genetic Engineering