Activation of NRF2 by epiberberine improves oxidative stress and insulin resistance in T2DM mice and IR-HepG2 cells in an AMPK dependent manner
Shunxiao Zhang, Sheng Zhang, Yan Zhang, Hua Wang, Yue Chen, Hao Lü
Topics & Concepts
Insulin resistanceOxidative stressGLUT4AMPKReactive oxygen speciesStreptozotocinProtein kinase BPharmacologyMalondialdehydeChemistryPI3K/AKT/mTOR pathwayInsulinBiochemistryBiologyInternal medicineEndocrinologyDiabetes mellitusMedicineSignal transductionProtein kinase AKinaseBerberine and alkaloids researchGenomics, phytochemicals, and oxidative stressBioactive natural compounds