Electrochemically promoted thio-Michael addition of <i>N</i>-substituted maleimides to thiols in an aqueous medium
Run Wu, Haojian Xu, Haiping Zhou, Pingbing Yu, Zhaoyue Wen, Wei Chen
Abstract
-substituted maleimides to various thiols in an aqueous medium. This protocol was found to be excellent in terms of facile scale-up, oxidant- and catalyst-free conditions, broad substrate scopes, good functional group tolerance, and easily available substrates. Notably, a plausible reaction mechanism was derived from the results of a series of control experiments and CV studies, which indicated that a radical pathway might speed up the thio-Michael addition under constant current.
Topics & Concepts
Thio-Michael reactionAqueous mediumElectrochemistryAqueous solutionChemistryOrganic chemistryCatalysisElectrodePhysical chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsPhenothiazines and Benzothiazines Synthesis and Activities