Palladium-Catalyzed Synthesis of 1,2-Diketones from Aryl Halides and Organoaluminum Reagents Using <i>tert</i>-Butyl Isocyanide as the CO Source
Bo Chen, Xiao‐Feng Wu
Abstract
In this work, an interesting and practical procedure for the synthesis of 1,2-diketones from aryl halides and organoaluminum reagents has been developed. Employing tert-butyl isocyanide as the CO source and palladium as the catalyst, the desired 1,2-diketones were isolated in good to excellent yields with good functional group tolerance. Concerning the reaction partners, besides aryl halides, both alkyl- and arylaluminum reagents were all suitable substrates here.
Topics & Concepts
ChemistryIsocyanideHalideReagentArylCatalysisPalladiumAlkylCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsChemical Synthesis and Analysis