Structural and Molecular Kinetic Features of Activities of DNA Polymerases
А. А. Кузнецова, Olga S. Fedorova, Nikita A. Kuznetsov
Abstract
DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis.
Topics & Concepts
DNA polymeraseDNA polymerase IIDNA clampPolymeraseDNA replicationGeneticsBiologyDNADNA polymerase deltaDNA polymerase muBiochemistryComputational biologyChemistryPolymerase chain reactionCircular bacterial chromosomeGeneReverse transcriptaseDNA Repair MechanismsHIV/AIDS drug development and treatmentDNA and Nucleic Acid Chemistry