Ultrasound-powered MXene hydrogels for enhancing tumor inhibition and immune stimulation by the piezoelectric effect
Ammavasi Chandran Ambigaibalan, Sivaraj Mehnath, Kannaiyakumar Dharshini, Murugaraj Jeyaraj
Abstract
studies show that the hydrogel offers great therapeutic efficacy to control tumor growth due to the combined effects of the piezoelectric effect and immune checkpoint blockade (ICB) therapy. It improves dendritic cell maturation and increases cytotoxic T-cells. Therefore, our work presents a novel piezoelectric hydrogel and new therapeutic strategies with great potential and versatility for treating breast cancers.
Topics & Concepts
ChemistryImmune systemCancer immunotherapyCytotoxic T cellCancer cellApoptosisAdjuvantCell biologyImmunotherapyCellEndoplasmic reticulumT cellImmune checkpointSelf-healing hydrogelsPiezoelectricityAntigenCancerBiophysicsSecretionLiposomeCancer researchControlled releaseNanotechnologyProgrammed cell deathDendritic cellCytotoxicityStimulationCell growthNanoplatforms for cancer theranostics3D Printing in Biomedical ResearchAdvanced Sensor and Energy Harvesting Materials