Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer’s disease
Keren Wang, Jian Shi, Yi Zhou, Ying He, Jing Mi, Jing Yang, Shuang Liu, Xiangcheng Tang, Wenmin Liu, Zhenghuai Tan, Zhipei Sang
Topics & Concepts
ChemistryIn vivoLead compoundIC50Cinnamic acidPharmacologyAntioxidantNeuroprotectionBiochemistryStereochemistryIn vitroCombinatorial chemistryBiotechnologyMedicineBiologyCholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments