Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis
K. Yamamoto, Noboru Nakata, Tetsu Mukai, Ikuro Kawagishi, Manabu Ato
Abstract
It has been reported that mycobacterial membrane protein large 5 (MmpL5), a resistance-nodulation-division (RND)-type inner membrane transporter in Mycobacterium tuberculosis ( Mtb ), is involved in the transport of antimycobacterial drugs. However, the functional roles of the membrane fusion protein mycobacterial membrane protein small 5 (MmpS5), organized as an operon with MmpL5, are unclear.
Topics & Concepts
EffluxAntimycobacterialMycobacterium tuberculosisOperonMembrane transport proteinMicrobiologyMembrane proteinATP-binding cassette transporterBiologyTransporterMycobacteriumTransport proteinTuberculosisCell biologyMembraneBacteriaBiochemistryGeneMedicineGeneticsEscherichia coliPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria