Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy
Quguang Li, Yifan Yan, Chunjie Wang, Ziliang Dong, Hao Yu, Minming Chen, Zhuang Liu, Liangzhu Feng
Abstract
T cell expansion through promoting the endo/lysosome escape and subsequent antigen cross-presentation of OVA. Resultantly, OVA@MnP vaccines upon subcutaneous vaccination elicited both prophylactic and therapeutic effects against OVA-expressing B16-F10 melanoma. Furthermore, the biomineralized autologous cancer vaccines prepared from the whole tumor cell lysates of the dissected tumors suppressed the growth of residual tumors, particularly in combination with anti-PD-1 immunotherapy. This study highlights a simple biomineralization approach for the controllable synthesis of cGAS-STING-activating autologous cancer vaccines to suppress postsurgical tumor relapse.