IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages
Xuefeng Wang, Liangyu Lin, Bin Lan, Yu Wang, Yu Wang, Liming Du, Xiaodong Chen, Qing Li, Keli Liu, Mingyuan Hu, Yueqing Xue, Arthur I. Roberts, Changshun Shao, Gerry Melino, Yufang Shi, Ying Wang, Ying Wang
Abstract
-ATPase (v-ATPase). This sequestrated assembly of v-ATPase inhibits the channeling of protons to lysosomes and leads to their rechanneling to mitochondria. An IGF2R-specific IGF2 mutant induces only the anti-inflammatory response and inhibits colitis progression. Together, our findings highlight a previously unidentified role of IGF2R activation in dictating anti-inflammatory macrophages.
Topics & Concepts
Property (philosophy)ProtonChemistryCell biologyBiologyPhysicsEpistemologyQuantum mechanicsPhilosophyEpigenetics and DNA MethylationGrowth Hormone and Insulin-like Growth FactorsDigestive system and related health