Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex
Yue Ban, Ting Yu, Bo Feng, Charlotte Lorenz, Xiaojia Wang, Clayton Baker, Yimin Zou
Abstract
mice were reduced by 50% at postnatal day 14. Prickle2 promotes synapse formation by antagonizing Vangl2 and stabilizing the intercellular complex of the planar cell polarity (PCP) components, whereas Prickle2 E8Q fails to do so. Coculture experiments show that the asymmetric PCP complexes can determine the presynaptic and postsynaptic polarity. In summary, the PCP components regulate the assembly and maintenance of a large number of glutamatergic synapses and specify the direction of synaptic transmission.
Topics & Concepts
GlutamatergicPolarity (international relations)PlanarIntracellularCell polarityCell biologyNeuroscienceBiophysicsCellChemistryBiologyGlutamate receptorComputer scienceBiochemistryReceptorComputer graphics (images)Photoreceptor and optogenetics researchCellular transport and secretionCRISPR and Genetic Engineering