Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca <sup>2+</sup> transfer for survival
César Cárdenas, Alenka Lovy, Eduardo Silva-Pavez, Félix A. Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabián Jaña, Pablo Cruz, Paula Farías, Elizabeth Mendoza, Hernán Huerta, Paola Murgas, Martin Hunter, Melany Ríos-Morales, Oscar Cerda, Irene Georgakoudi, Armen Zakarian, Jordi Molgó, J. Kevin Foskett
Abstract
transfer may represent a general therapeutic strategy against cancer cells regardless of their OXPHOS status.
Topics & Concepts
Endoplasmic reticulumOxidative phosphorylationMitochondrionCell biologyPhosphorylationChemistryBiologyBiochemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismEndoplasmic Reticulum Stress and Disease