Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection
Kelly L. Michie, Justine L. Dees, Derek Fleming, Dina A. Moustafa, Joanna B. Goldberg, Kendra P. Rumbaugh, Marvin Whiteley
Abstract
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality worldwide. To survive in both the environment and the host, P. aeruginosa must cope with redox stress. In P. aeruginosa , a primary mechanism for protection from redox stress is the antioxidant glutathione (GSH). GSH is a low-molecular-weight thiol-containing tripeptide ( l -γ-glutamyl- l -cysteinyl-glycine) that can function as a reversible reducing agent.
Topics & Concepts
GlutathionePseudomonas aeruginosaTripeptideBiologyOxidative stressMicrobiologyAntioxidantGlycineBiochemistryBacteriaAmino acidEnzymeGeneticsSulfur Compounds in BiologyNanoplatforms for cancer theranosticsRedox biology and oxidative stress