Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice
Zhen‐Guo Ma, Chun‐Yan Kong, Hai‐Ming Wu, Peng Song, Xin Zhang, Yu‐Pei Yuan, Wei Deng, Qizhu Tang
Abstract
These findings suggest that TLR5 deficiency attenuates DOX-induced cardiotoxicity in mice, and targeting TLR5 may provide feasible therapies for DOX-induced acute cardiotoxicity.
Topics & Concepts
CardiotoxicityTLR5PharmacologyMedicineDoxorubicinToll-like receptorReceptorInternal medicineChemotherapyInnate immune systemChemotherapy-induced cardiotoxicity and mitigationElectron Spin Resonance StudiesTakotsubo Cardiomyopathy and Associated Phenomena