Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption
Zhenling Zhang, Qiuping Zhang, Li Fang, Yi Xin, Zhijun Duan
Abstract
injection. Conversely, ZnPP completely reversed these effects. Furthermore, mice with intestinal epithelial HO-1 deficient exhibited a robust increase in mucosal TJs disruption, cleaved caspase-3 expression, and MAPKs activation as compared to the control group mice. These data demonstrated that HO-1-dependent MAPK signaling inhibition preserves the intestinal mucosal barrier integrity by abrogating TJ dysregulation and epithelial cell damage. The differential targeting of gut HO-1-MAPK axis leads to improved intestinal disease therapy.
Topics & Concepts
MAPK/ERK pathwayCell biologyBiologyPharmacologyChemistryMedicineSignal transductionHeme Oxygenase-1 and Carbon MonoxideNeonatal Health and BiochemistryBarrier Structure and Function Studies