Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4 <sup>+</sup> T cells ex vivo
Dawei Zhou, Tsuyoshi Hayashi, Maxime Jean, Weili Kong, Guillaume Fiches, Ayan Biswas, Shuai Liu, Hailemichael O. Yosief, Xiaofeng Zhang, Jay Bradner, Jun Qi, Wei Zhang, Netty Santoso, Jian Zhu
Abstract
T cells. Our findings demonstrate that HIV-1 infection hijacks PLK1 to prevent cell death induced by viral cytopathic effects, and that PLK1 is a promising target for chemical "killing" of HIV-1 reservoir cells.
Topics & Concepts
Ex vivoPLK1Polo-like kinaseVirologyKinaseHuman immunodeficiency virus (HIV)In vivoBiologyCell biologyBiochemistryGeneticsCell cycleCellHIV Research and TreatmentViral-associated cancers and disordersCytomegalovirus and herpesvirus research